Am J Clin Exp Immunol 2012;1(1):28-32.
Potential roles of IL-9 in the pathogenesis of systemic lupus erythematosus
Rui-Xue Leng, Hai-Feng Pan, Dong-Qing Ye, Yuekang Xu
Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road,
Hefei, Anhui, 230032, PR China; Anhui provincial laboratory of population health & major disease screening and
diagnosis, Anhui Medical University, 81 Meishan Road, Hefei, Anhui 230032, PR China; Department of Biochemistry &
Molecular Biology, The University of Melbourne, Victoria 3010, Australia.
Received March 25, 2012; accepted April 11, 2012; Epub April 23, 2012; Published June 30, 2012
Abstract: T helper (Th) cells and their cytokines play a pleiotropic role in the pathogenesis of systemic lupus
erythematosus (SLE). Recently, a new effector T cell subset, Th9 cells, which preferentially secrete IL-9, has been
identified. IL-9 is mainly produced by several T cell subsets including Th9 and Th17, and effective on the functions of Th
cells and mast cell. However, there are no unambiguous conclusions that IL-9 contributes to the pathogenesis of SLE.
Recently, IL-9 was reported to mediate profound anti-inflammatory effects in several cells or experimental autoimmune
models. In particular, IL-9 production seemed to be important in mast cell recruitment. Defect in IL-9/IL-9R axis exhibited
a more severe course of Experimental Autoimmune Encephalomyelitis (EAE) and enhanced activity of Tregs, phenotypes
reminiscent of SLE. Consistently, IL-9 was implicated in the proliferation of several types of CD4+ T cells, indicating that
IL-9 may be therapeutically relevant in SLE. In this article, we briefly discuss the biological features of IL-9 and
summarize recent advances on the role of IL-9 in the pathogenesis and treatment of SLE. (AJCEI1203001).
Address all correspondence to:
Dong-Qing Ye, MD, PhD
Department of Epidemiology and Biostatistics
School of Public Health, Anhui Medical University
81 Meishan Road, Hefei, Anhui, 230032, PR China.
Tel: +86 551 5167726; Fax: +86 551 5161171
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