Am J Clin Exp Immunol 2012;1(2):147-153

Review Article
Regulation of Ras signal transduction during T cell development and

Philip E Lapinski, Philip D King

Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA

Received October 10, 2012; Accepted November 5, 2012; Epub November 15, 2012; Published November 30, 2012

Abstract: T cell receptor-induced activation of the Ras signaling pathway is essential for T cell development, proliferation
and differentiation. Given the central role of Ras in T cell biology its activation must be tightly regulated. However,
precisely how Ras activation is controlled in T cells is not completely understood. In this review, we provide a summary
of the known factors and mechanisms involved in positive and negative regulation of Ras activation in the T cell lineage.

Keywords: T cells, T cell development, T cell activation, T cell receptor, signal transduction, Ras, Ras GTPase-activating
proteins, Ras guanine nucleotide exchange factors

Address all correspondence to:
Dr. Philip E Lapinski, or Dr. Philip D King
Department of Microbiology and Immunology
University of Michigan Medical School
Ann Arbor, MI 48109, USA.
E-mail: (PEL); (PDK)
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