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Am J Clin Exp Immunol 2013;2(2):172-185
Original Article
The oxidase activity of vascular adhesion protein-1 (VAP-1) is essential for
function
Thomas Noonan, Susan Lukas, Gregory W Peet, Josephine Pelletier, Mark Panzenbeck, Adedayo Hanidu, Suzanne
Mazurek, Ruby Wasti, Irina Rybina, Teresa Roma, Anthony Kronkaitis, Alycia Shoultz, Donald Souza, Huiping Jiang,
Gerald Nabozny, Louise Kelly Modis
Boehringer Ingelheim Pharmaceuticals, 900 Ridgebury Road, Ridgefield, CT 06877
Received May 14, 2013; Accepted May 29, 2013; Epub June 15, 2013; Published June 30, 2013
Abstract: Vascular adhesion protein-1 (VAP-1) has been implicated in the pathogenesis of inflammatory diseases and
is suggested to play a role in immune cell trafficking. It is not clear whether this effect is mediated by the oxidase activity
or by other features of the protein such as direct adhesion. In order to study the role of VAP-1 oxidase activity in vivo, we
have generated mice carrying an oxidase activity-null VAP-1 protein. We demonstrate that the VAP-1 oxidase null mutant
mice have a phenotype similar to the VAP-1 null mice in animal models of sterile peritonitis and antibody induced
arthritis suggesting that the oxidase activity is responsible for the inflammatory function of VAP-1. (AJCEI1305001).
Keywords: Vascular adhesion protein-1 (VAP-1), semicarbazide-sensitive amine oxidase, immune cell trafficking,
oxidase activity, inflammatory function
Address correspondence to: Dr. Louise Kelly Modis, Boehringer Ingelheim Pharmaceuticals, 900 Ridgebury Road,
Ridgefield, CT 06877, USA. Phone: 203-791-6596. E-mail: Louise-Kelly.Modis@boehringer-ingelheim.com
Original Article
The oxidase activity of vascular adhesion protein-1 (VAP-1) is essential for
function
Thomas Noonan, Susan Lukas, Gregory W Peet, Josephine Pelletier, Mark Panzenbeck, Adedayo Hanidu, Suzanne
Mazurek, Ruby Wasti, Irina Rybina, Teresa Roma, Anthony Kronkaitis, Alycia Shoultz, Donald Souza, Huiping Jiang,
Gerald Nabozny, Louise Kelly Modis
Boehringer Ingelheim Pharmaceuticals, 900 Ridgebury Road, Ridgefield, CT 06877
Received May 14, 2013; Accepted May 29, 2013; Epub June 15, 2013; Published June 30, 2013
Abstract: Vascular adhesion protein-1 (VAP-1) has been implicated in the pathogenesis of inflammatory diseases and
is suggested to play a role in immune cell trafficking. It is not clear whether this effect is mediated by the oxidase activity
or by other features of the protein such as direct adhesion. In order to study the role of VAP-1 oxidase activity in vivo, we
have generated mice carrying an oxidase activity-null VAP-1 protein. We demonstrate that the VAP-1 oxidase null mutant
mice have a phenotype similar to the VAP-1 null mice in animal models of sterile peritonitis and antibody induced
arthritis suggesting that the oxidase activity is responsible for the inflammatory function of VAP-1. (AJCEI1305001).
Keywords: Vascular adhesion protein-1 (VAP-1), semicarbazide-sensitive amine oxidase, immune cell trafficking,
oxidase activity, inflammatory function
Address correspondence to: Dr. Louise Kelly Modis, Boehringer Ingelheim Pharmaceuticals, 900 Ridgebury Road,
Ridgefield, CT 06877, USA. Phone: 203-791-6596. E-mail: Louise-Kelly.Modis@boehringer-ingelheim.com
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